Involvement of connexin43 hemichannel in ATP release after -irradiation

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Involvement of connexin43 hemichannel in ATP release after γ-irradiation

Ionizing radiation induces biological effects not only in irradiated cells but also in non-irradiated cells, which is called the bystander effect. Recently, in vivo and in vitro experiments have suggested that both gap junction hemichannel connexin43 (Cx43) and extracellular adenosine triphosphate (ATP) released from cells play a role in the bystander effect. We have reported that γ-irradiation...

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Connexin43 Hemichannel-Mediated Regulation of Connexin43

BACKGROUND Many signaling molecules and pathways that regulate gap junctions (GJs) protein expression and function are, in fact, also controlled by GJs. We, therefore, speculated an existence of the GJ channel-mediated self-regulation of GJs. Using a cell culture model in which nonjunctional connexin43 (Cx43) hemichannels were activated by cadmium (Cd(2+)), we tested this hypothesis. PRINCIPA...

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Gap junctional hemichannel-mediated ATP release and hearing controls in the inner ear.

Connexin gap junctions play an important role in hearing function, but the mechanism by which this contribution occurs is unknown. Connexins in the cochlea are expressed only in supporting cells; no connexin expression occurs in auditory sensory hair cells. A gap junctional channel is formed by two hemichannels. Here, we show that connexin hemichannels in the cochlea can release ATP at levels t...

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ژورنال

عنوان ژورنال: Journal of Radiation Research

سال: 2012

ISSN: 0449-3060,1349-9157

DOI: 10.1093/jrr/rrs014